Dynein: Domains, Structures, and Movements

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Video Reflection
1. Name the different domains in Dynein
AAA1, AAA2, AAA3, AAA4, AAA5, AAA6
2. Looking at the Structure of Dynein; Notre Dame Cathedral in Paris and Dynein share the presence of Buttresses, what is the role of the Buttress for both of them?
Buttress in dynein and the Cathedral in Paris play the role of additional exterior support of the structure, strengthening it and ensuring the structure withstands side thrusts created by the load on the roof or the structure's stack. It also helps transfer the force of the structure down to the ground instead of letting it fester all over the structure.
3. Dynein functions with another complex to transport vesicles, what’s the name of this complex? Cytoplasmic dynein.4. Dynein belongs to a protein family we already got to know, what is the protein family name? Cytoskeletal motor protein.5. Which conformational changes are needed for Dynein movements?
The conformational changes required are for the AAA1 domain, which facilitates hydrolysis to come closer together with the AAA2 domain. They close the large gap between them, thereby leading to conformational changes around the ring, which are transmitted to the microtubule-binding domain and linker, bringing about the desired change.
6. When is ATP hydrolyzed?
ATP is hydrolyzed when AAA1 and AAA2 domains bridge the gap between them, enabling ATP to bind and bring together residues that contribute to hydrolysis. 
7. Explain Redocking
Redocking is the process by which a dyn...