Di-2-Ethylhexyl terephthalate (DEHP)

Di-2-Ethylhexyl terephthalate (DEHP)
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Chemical: Di-2-Ethylhexyl terephthalate (DEHP)
Carpenter, Weil, and Smyth's (1953) study centered on an in-depth examination of the chronic oral toxicity of DEHP in rats, guinea pigs, and dogs. The researchers administered DEHP orally to these animals over an extended period, aiming to unravel the long-term effects of DEHP exposure across different species. This study, published in the Archives of Industrial Hygiene and Occupational Medicine, is a foundational exploration of DEHP's chronic toxicity. By analyzing various parameters such as absorption, distribution, metabolism, and elimination, the researchers provided detailed insights into the toxicity levels of DEHP in these animals. Their work not only deepened our understanding of DEHP's effects but also laid the groundwork for assessing potential risks to human health arising from exposure to this compound.
The National Toxicology Program (1982) extended this exploration by conducting a comprehensive carcinogenesis bioassay of DEHP in F344 rats and B6C3F1 mice. This in-depth study was documented in NIH Pub. No. 82-1771 involved a feed study where the animals were systematically exposed to DEHP for a specified period. The primary objective was to assess DEHP's carcinogenic potential, particularly concerning prolonged exposure scenarios. This study provided critical insights into the potential link between DEHP exposure and cancer development in these animal models by meticulously analyzing tumor incidence, latency periods, and histopathological changes. The results of this bioassay have profound implications for understanding the compound's carcinogenicity, offering vital data for regulatory decisions and public health initiatives.