Biology 101 Bourdon, and Bernard Focused on DNA Methylation

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Biology 101
The article by Shin, Bourdon, and Bernard focused on DNA methylation (DNAm) and gene expression in healthy individuals. The purpose of the article was to determine how to control DNAm and gene expression using three different cohorts comprising of adolescents and adults, and to determine the risk of multiple sclerosis. The use of adolescents and adults in the sample was intentional so as to establish whether the association between DNAm and gene expression is influenced by age. To answer the first question on whether the largest component of shared variance can be genetically determined, the authors conducted a principal component analysis of CpGs. The second question was whether the DNAm at the CpGs is heritable.
The article revealed that DNAm and gene expression can be controlled. The long-range meQTL is effective in c...