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Pages:
1 page/β‰ˆ275 words
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Style:
APA
Subject:
Health, Medicine, Nursing
Type:
Essay
Language:
English (U.S.)
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MS Word
Date:
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Topic:

Pathogenesis of Polycystic Ovarian Syndrome

Essay Instructions:

QUESTION 1
Scenario 1: Polycystic Ovarian Syndrome (PCOS)
A 29-year-old female presents to the clinic with a complaint of hirsutism and irregular menses. She describes irregular and infrequent menses (five or six per year) since menarche at 11 years of age. She began to develop dark, coarse facial hair when she was 13 years of age, but her parents did not seek treatment or medical opinion at that time. The symptoms worsened after she gained weight in college. She got married 3 years ago and has been trying to get pregnant for the last 2 years without success. Height 66 inches and weight 198. BMI 32 kg.m2. Moderate hirsutism without virilization noted. Laboratory data reveal CMP within normal limits (WNL), CBC with manual differential (WNL), TSH 0.9 IU/L SI units (normal 0.4-4.0 IU/L SI units), a total testosterone of 65 ng/dl (normal 2.4-47 ng/dl), and glycated hemoglobin level of 6.1% (normal value ≤5.6%). Based on this information, the APRN diagnoses the patient with polycystic ovarian syndrome (PCOS) and refers her to the Women’s Health APRN for further workup and management.
Question
1. What is the pathogenesis of PCOS?

Essay Sample Content Preview:

Pathogenesis of Polycystic Ovarian Syndrome
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Pathogenesis of Polycystic Ovarian Syndrome
The pathogenesis of polycystic ovarian syndrome has not been precisely established. However, several mechanisms have been suggested to play a significant role in the development of the condition. The first mechanism involves an abnormality in the production of hormones. For instance, the affected person's body may produce abnormal levels of androgens and estrogen. Evidence has revealed that patients with this condition often present with high levels of testosterone and androstenedione, among others (Aversa et al., 2020). It is worth noting that levels of these hormones vary between patients.
The second mechanism that has been associated with the development of polycystic ovarian syndrome is insulin resistance. Experts have suggested that elevated insulin levels may interfere with the normal working of gonadotropins (Zeng et al., 2020). High insulin levels may also interfere with the ovaries' normal functioning, leading to polycystic ovarian syndrome. Evidence has further shown that the effects of insulin are more elevated when the affected person is e...
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