Rapid Epidermal Proliferation in Patient with Psoriasis and the Causes of Cardiogenic Shock

Advanced Pathophysiology (Lesson 16): Alterations in Integument Function and Multi-System Function
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Advanced Pathophysiology: Lesson 16: Alterations in Integument Function and Multi-System Function
1 Mr. Delgattio has psoriasis. Why would rapid epidermal proliferation cause thick, silvery, erythematous plaques?
Rapid epidermal proliferation would cause thick, silvery, and erythematous plaques in patients with psoriasis such as in the case of Mr. Delgattio. Usually, in psoriasis excessive proliferation of keratinocytes causes the thickening of the skin (Zhang et al., 2015). Other causes of thickening include expanded dermal vasculature, altered keratinocyte differentiation, inflammation, and lymphocyte and neutrophils infiltration. Rapid epidermal shedding causes the lesions to be scaly. The normal epidermal shedding is usually 14-20 days, but in psoriasis, this is reduced to 3-4 days (Huether & McCance, 2012). In addition, increased numbers of germinative cells as well as extended transit time of cells via the dermis can result in plaques. Since rapid cell proliferation fails to allow time for keratinization and maturity of cells, this results in thickening of the skin and formation of plaque.
2 What is cardiogenic shock and what causes it?