Hypothyroidism As A Major Contributor To Hyperlipidemia

Hyperlipidemia
Name:
Course:
Instructor:
Date:
Introduction
Hyperlipidemia also known as hypercholesterolemia or high cholesterol tends to be the major risk factor for the heart disease. In the US, the condition has been termed as the leading cause of death. One in every three of Americans is affected (Davis, 2017).There are two types of hyperlipidemia; low-density lipoprotein (LDL) and high-density lipoprotein (HDL). The earlier is referred to as bad cholesterol while the later is good cholesterol. Hypothyroidism is a major contributor to hyperlipidemia. To lower LDL and raise HDL, regular exercise is recommended. This paper synthesizes information from the existing literature and identifies gaps in the literature that require further research. It also discusses the diagnosis and treatment of hyperlipidemia.
Literature Review
Studies by Nelson Robert 2013, suggest that the major risk factor for cardiovascular disease is hyperlipidemia. The study also suggests that the treatment of the condition is based on the guidelines of the National Cholesterol Educational Panel’s (NCEP) Adult Treatment Program-3 (ATP-III). To raise the LDL-C, statins are the best-recommended category of drugs. To substitute Statins, other categories of drugs are used. They include; dietary supplements, niacin, fibrates, and ezetimibe. The study too suggests that the aggressiveness of the ATP-III guidelines is still questionable. There are ATP-IV guidelines, but they have not been put into practice yet. There are some uncertainties that the physicians are still facing. The lowest level of targeting LDL-C is uncertain. There is no assurance if HLD-C should be treated pharmacologically among others.
Studies by Mannu, Zaman, Rehman & Myint (2013) affirm that the leading cause of death in the world is Coronary Heart Diseases (CHD). The major causality of CHD is hypercholesterolemia. Non-pharmacological methods which include lifestyle modification provide both long-term and initial measures through which the issue can be addressed. This was a systematic search study of Medline/PubMed which involved an approach that can be described as two-tier. It was limited to the materials written in English. It involved reviewing more than 3600 reports. The results indicate that change in lifestyles regarding dietary habits, physical activities, and weight reduction helped to achieve the target level of cholesterol in the body. Constituents of dietary for instance green tea, soy protein and plant sterols played a vital role in achieving these goals. The pharmacological interventions were recommended where non-pharmacological interventions did not work for a period of 3 weeks.
Studies by Shattat 2017, suggest that hyperlipidemia serves as a major risk factor for contracting the cardiovascular disease. The major anti-hyperlipidemia stands to be statins and fibrates for the treatment of triglycerides and plasma cholesterol that is elevated. However, there is a potential treatment from other agents such as the following. The agents include; ATP citrate lyase inhibitors, diacyl glycerol acyl transferase inhibitors, squalene epoxidase inhibitors and lanosterol synthase inhibitors. This was a study that focused on reviewing hyperlipidemia types, met...