Relationship Between DNA, Chromosomes, and Cell Division

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Biology 101
The article by Brangwynne and Marko, published in nature international journal of science in 2016 expounds more on the relationship between DNA, chromosomes, and cell division. The authors point out that DNA is packaged into chromosomes, which are then separated from each other during cell division. The article sought to answer why and how the chromosomes are able to remain separate during cell division.
The reason for the separation was revealed by Brangwynne and Marko (234) as due to the presence of Ki-67 protein, which is responsible for coating the chromosomes during cell division. The initial stage of mitosis involves separation of chromosomes from each other when the nucleus membrane breaks, and the chromosomes are pulled to the dividing cell’s poles. The Ki-67 protein ensures that once the nucleus membranes are broken down, the ch...