Viral Infection: Side Effects of Medications for Influenza

Viral Infection
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Influenza is a viral infection caused by the influenza virus. The illness is characterized by its contagiousness, which causes respiratory diseases. It infects the respiratory system, including the nose, throat, and lungs. The virus is classified into types A and B. If left untreated, the influenza symptoms can have life-threatening complications. Common symptoms of the virus include fever, aching muscles, sweat and chills, sore throat, headaches, fatigue, and a stuffy nose. There are various antiviral drug options for influenza, including oral baloxavir, peravamir, Oseltamivir, and zanamivir. Oseltamivir is a critical drug option for treating infections caused by influenza A and B virus.
Genetic polymorphisms significantly affect Oseltamivir's interaction with neuraminidases, metabolism, and transport. Oseltamivir metabolism's main enzyme, CESI, presents a genetic polymorphism responsible for the conformation change of the protein that produces enzymes with slow or no activity. The drug's resistance can be preexisting or emerge during therapy. The mechanism of action i...