The Contribution of Inflammation to the Development of Atherosclerosis
Myocardial Infarction
CC: “I woke up this morning at 6 a.m. with numbness in my left arm and pain in my chest. It feels tight right here (mid-sternal).” “My dad had a heart attack when he was 56-years-old and I am scared because I am 56-years-old.”
HPI: Patient is a 56-year-old Caucasian male who presents to Express Hospital Emergency Department with a chief complaint of chest pain that radiates down his left arm. He states this started this morning and has been getting worse, pointing to the mid-sternal area, “it feels like an elephant is sitting on my chest and having a hard time breathing”. He rates the pain as 9/10. Nothing has made the pain better or worse. He denies any previous episode of chest pain. Denies nausea, or lightheadedness. Nitroglycerin 0.4 mg tablet sublingual x 1 which decreased pain to 7/10.
Lipid panel reveals Total Cholesterol 424 mg/dl, high density lipoprotein (HDL) 26 mg/dl, Low Density Lipoprotein (LDL) 166 mg/dl, Triglycerides 702 mg/dl, Very Low-Density Lipoprotein (VLDL) 64 mg/dl
His diagnosis is an acute inferior wall myocardial infarction.
Question:
1. How does inflammation contribute to the development of atherosclerosis?
Concepts of Cardiovascular and Respiratory Disorders
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Concepts of Cardiovascular and Respiratory Disorders
Atherosclerosis manifests itself in a variety of ways depending on the individual. Some people will remain asymptomatic for the rest of their lives, despite the presence of atherosclerotic lesions in their capillaries. Others may suffer from ischemia indications, such as cardiovascular disorders, strokes among other things (Wolf et al., 2014). Clinical signs of an atheroma commonly manifest in adulthood and are characterized by thrombosis. Inflammation is highly frequent in cases of atherosclerosis, and the symptoms of inflammation may even play a role in the development of the illness in certain instances.
Atherosclerotic lesions have similar inflammation characteristics to those seen in normal inflammatory and autonomic dysfunction (Wolf, & Ley, 2019). A continuous, low-grade inflammation associated with atherosclerosis draws cells from both the adaptive and innate immune into the plaque. As a result, atherosclerosis is characterized as a persistent inflammation with an autoimmune component (Galkina & Ley, 2009). A faulty interaction between the immune system and lipids is also a characteristic of ...
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