Osteoarthritis and Rheumatoid Arthritis and the Pathophysiology of Osteogenesis Imperfecta

Discussion
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DISCUSSION
Question 1
It is indeed true that both osteoarthritis and rheumatoid arthritis present similar symptoms like joint pain and stiffness. However, the main difference between the two diseases is the cause of the joint symptom. For example, it is caused by mechanical tear and wears on the joints, and it starts in an isolated joint. On the other hand, rheumatoid arthritis is an autoimmune illness whereby the body's immune system attacks the joints (Pincus et al., 2019). Although both diseases cause inflammation in the joints, rheumatoid arthritis causes severe inflammation. Consequently, rheumatoid arthritis can cause fever and flu-like signs, while the symptoms of osteoarthritis are limited to joints.
Question 2
Children born with osteogenesis imperfecta are indeed at risk for pathological fractures. The common type of osteogenesis imperfect is caused by a mutation in the two collagen type I genes. Accor...