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Essay Available:
Pages:
1 page/β‰ˆ275 words
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2 Sources
Style:
APA
Subject:
Health, Medicine, Nursing
Type:
Coursework
Language:
English (U.S.)
Document:
MS Word
Date:
Total cost:
$ 5.83
Topic:

Muscarinic Antagonists and Agonists for Hyperhidrosis

Coursework Instructions:

Choose either a muscarinic agonist or antagonist agent and provide an appropriate indication for use. Share the mechanism of action of this medication and hints for monitoring, side effects, and drug interactions, including interactions with CAM, ethnic, cultural, and genetic differences. What other considerations need to be made when prescribing these medications in relation to other systems and receptors? Include the name of the medication in the subject line so that the medications can be followed. Include references using APA format.

Coursework Sample Content Preview:

Discussion: 1
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Question 1
Muscarinic antagonists and agonists are regularly used to regulate immoderate sweating and cure hyperhidrosis (excessive sweating). In addition, muscarinic agonists such as atropine are used to treat diseases caused by extreme activities of muscarinic receptors. In contrast, muscarinic antagonists are used to cure disorders caused by a lack of sufficient muscarinic receptors or none (Pleuvry, 2004). Muscarinic agonists are divided into five classified as; M1, M2, M3, M4, and M5. M1, M3, and M5 are transmembrane receptors that join together to form the G9 protein, which upregulates phospholipase C (PLC) (Toai, 2021). In addition, the PLC sticks to phosphatidylinositol 4, 5-biphosphate (PIP2) into 1,2diacylglycerol (DAG) and Inositol 1, 4, 5, triphosphate (IP3). DAG activates protein kinase C, which activates the downstream protein and causes calcium influx. Additionally, IP3 causes the sarcoplasmic reticulum to discharge stored calcium. Thus the increased intracellular calcium enhances the contraction of muscles and exocrine glandular secretion.
On the other hand, M2 and M4 receptors are Gi receptors that obstruct adenylyl cyclase. The inhibition reduces adenosine 3'5', monophosphate (cAMP) production from ATP. Therefore, a decrease in cAMP concentration consequently decreases the activation of Kinase A protein. (Toai, 2021)
Question 2
A majority of body activities are controlled by neurotransmitters acetylcholine. Also, activities such as sweating a...
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