Lumateperone Medication: Patient Education Consideration

Lumateperone Medication
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Lumateperone Medication: Patient Education Consideration
Lumateperone is a drug used to manage mental and mood disorders, especially schizophrenia. It comes in the form of lumateperone tosylate. Lumateperone is classified as an atypical antipsychotic. Atypical antipsychotics, also called second-generation antipsychotics and serotonin–dopamine antagonists, are often prescribed to treat schizophrenia and complement the treatment of major depressive disorder (MDD), schizoaffective disorder, and bipolar disorder (Correll et al.,2021). The mechanism of action of lumateperone entails concurrent activation of serotonin, dopamine, and glutamate neurotransmission (Correll et al.,2021). These key targets have been found to play a role in severe mental illness. Lumateperone is a potent serotonin receptor antagonist and a dopamine receptor presynaptic partial agonist and postsynaptic antagonist. It is also a serotonin reuptake inhibitor and a dopamine receptor-dependent modulator of glutamate.
Nursing management should focus on patient assessment and education about lumateperone use in terms of drug administrations, specific contraindications, possible side effects, and special consideration when taking this drug.
Lumateperone is taken orally. It has been approved Food and Drug Administration (FDA) at dosage is 42-mg capsules (Cooper & Gupta, 2021). It is recommended to be taken during bedtime. Intake of a high-fat meal lowers the maximum serum concentration. Thus, meals with high fat should be discouraged during lumateperone administration. There is special dietary consideration when administering lumateper...