Screening for Diseases: Test Sensitivity and Specificity

Screening for Diseases
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1] What would be the impact on this test's sensitivity if you moved the cutoff for a positive result from A to B? What about specificity? What would happen to sensitivity and specificity if you moved the cutoff from A to C? Where would you put the cutoff for this test? What is the relationship between sensitivity and specificity for any given test?
The sensitivity of the screening test relates to the ability to identify individuals who are affected by HIV, without showing false negative results (Friis & Sellers, 2009). On the other hand, specificity is the ability of the test to correctly identify individuals who are unaffected and increasing the cutoff point to point B will increase the specificity compared to the sensitivity. Moving the cutoff to C will lower the specificity, since more people who are unaffected will grouped as being diseased. The best cutoff point is at A, as this maximizes sensitivity and the specificity. There is an inverse relationship between sensitivity and specificity, when the screening tests are more efficient there is a lower false-positive rate. The sensitivity of the test relates to the proportion of people are infected and test positive, and the specificity represents those who are unaffected and the test correctly shows negative results.
2] Where would the director of the Blo...