A draft Sequence of the Neandertal Genome

A DRAFT SEQUENCE OF THE NEANDERTAL GENOME
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(14 October 2010)
A Draft Sequence of the Neandertal Genome
This research was carried out to present genome that is composed of more than four billion nucleotides from three different individuals. It compares Neandertal genome to the genome of five nowadays humans worldwide. It identifies many genome areas that might have been affected by positive selection of in ancestral modern humans, (Green, Et al, 2010).
The hypotheses are; Neanderlands are closer to non-Africans than to Africans. Segments of Neandertal ancestry is non-African genome. Another one was Non-Africans haplotypes match Neandertals unexpectedly often. Another hypothesis is that an evolutionary change in RUNX2 was of importance in the origin of modern humans and that this change influenced morphological aspect of the upper body and cranium, (Green, Et al, 2010).
The conclusion of the study is that Neandertals shared more genetic variance with present day humans in Eurasia than with nowadays humans in sub-Saharan Africa. The conclusion sheds light broader issues concerning the gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasia groups from one another.
The questions asked are: are Neandertals closer to non-Africans than to Africans? Are segments of ancestry in non-Africa genomes? Was evolutionary change in RUNX2 of importance in the origin of modern humans? And does this change influenced morphological aspect of the upper body and cranium? (Green, Et al, 2010). The problem with these methods of DNA retrieval is that though PCR of ancient DNA can be multiplexed, it does not allow a larger proportion of the genome of an organism, hence can`t use larger proportion of organisms, (Green Et al. 2010).
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