Research Proposal for Diabetic Foot Ulcer

Research Proposal for Diabetic Foot Ulcer - Type 2 - The effectiveness of Honey dressing therapy versus iodine dressing therapy in the management of neuropathic diabetic foot ulcers Table of Contents 1 Abstract4 2 Introduction5 3 Literature Review7 * Studies related to foot ulcer7 * Studies related to honey and iodine dressing therapies9 * Qualities of life of DFU patients13 4 Aim15 5 Objectives15 6 Hypotheses15 7 Conceptual Framework15 8 Proposed Research Focus/Justification for the Study16 9 Proposed Methodology17 * Setting17 * Research Design17 * Sampling Procedure17 * Search Strategy17 * Sampling Criteria18 * Inclusion18 * Exclusion18 * Sampling Technique18 10 Data Collection18 Instruments19 Data Analysis19 Pilot Study20 Variables20 * Independent Variables20 * Dependent Variables20 Projected Outcomes20 Ethical Considerations21 Limitation References Abstract Diabetic neuropathy is the common factor in almost 90% of diabetic foot ulcers. Nerve damage in diabetes affects the motor, sensory, and autonomic fibers. Motor neuropathy causes muscle weakness, atrophy, and paresis. Sensory neuropathy leads to loss of the protective sensation of pain, pressure, and heat. Autonomic dysfunction causes vasodilation and decreased sweating, resulting in a loss of skin integrity, providing a site vulnerable to microbial infection. The aim of the proposed study is to determine which of the two therapies; honey dressing versus iodine dressing is more effective in treating Diabetic Foot Ulcers in terms of measuring the percentage of improvement of healing, cost and the participants’ quality of life. Both qualitative and quantitative studies will be conducted. The study will be performed in various local Podiatry clinics setting for 12 months from September 2018 till September. Patients with diabetes mellitus (DM) type 2 and neuropathic foot ulcers will be recruited and following informed consent will be randomly assigned to group A (Honey dressing) or group B (iodine dressing) followed by daily dressing changes and a standardized offloading device will be used. The time to heal, quality of life and the accumulative costs of each intervention will be recorded up to 12 months which will be the end point of the study. The end point of the study month 12 at that time we will measure all the ulcers and describe the ulcers as a percentage healing from the baseline to the end of the study, the healing will be measurement from the baseline of healing. Inferential statistics will be done to analyze the quantitative data. The statistical analysis will be using the chi-square, Friedman, and Dunn tests with a significance level of < 5% (P < 0.05). Thematic analysis will be used to analyze the qualitative data. A purposive sample from the main study (both groups) will be selected for interview in order to gain insight into the patient’s experiences of each dressing in relation to quality of life.Key Words: Honey dressing, Iodine dressing and Diabetic Foot Ulcers, diabetes type 2, age.  Introduction Diabetes is the major cause of non-traumatic lower extremity amputations in developed countries. This is due to untreated foot ulcers and they exist as a result of other complications ...